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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Candidate gene polymorphisms in eating disorders
A Hinney1, H Remschmidt, J Hebebrand
1Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps-University of Marburg, Hans-Sachs-Str. 6, D-35033, Marburg, Germany. hinneya@post.med.uni-marburg.de
European Journal of Pharmacology
|January 3, 2001
Summary
Genetic studies explore the biological underpinnings of anorexia nervosa and bulimia nervosa. Current research investigates gene variations, particularly in the serotonin system, to identify causes of these eating disorders.
Area of Science:
- Psychiatry
- Genetics
- Neuroscience
Background:
- Anorexia nervosa and bulimia nervosa are complex eating disorders with disturbed attitudes towards weight and body shape.
- Genetic factors, neurotransmitter systems, and personality traits are implicated in their etiology.
- Previous candidate gene studies have yielded inconsistent results.
Purpose of the Study:
- To review the current understanding of genetic influences on anorexia nervosa and bulimia nervosa.
- To evaluate the evidence for specific gene associations, such as the 5-HT(2A) gene polymorphism.
- To highlight the need for further genetic research, including genome-wide screenings.
Main Methods:
- Review of genetic association and transmission disequilibrium studies on candidate genes.
- Analysis of studies focusing on the serotonergic system and body weight regulation genes.
- Mention of ongoing large-scale genetic studies and meta-analyses.
Main Results:
- Most candidate gene studies have produced negative or inconclusive results.
- An association between the 5-HT(2A) gene promoter polymorphism (-1438 G/A) and anorexia nervosa has been suggested but not consistently confirmed.
- Meta-analyses have not supported this association.
Conclusions:
- Candidate gene approaches have not definitively identified susceptibility genes for eating disorders.
- Genome-wide screenings are necessary to discover novel genes involved in anorexia nervosa and bulimia nervosa.
- Continued genetic research may lead to new pharmacological treatments for eating disorders.
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