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Single Nucleotide Polymorphisms-SNPs01:05

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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Published on: November 3, 2010

Candidate gene polymorphisms in eating disorders.

A Hinney1, H Remschmidt, J Hebebrand

  • 1Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps-University of Marburg, Hans-Sachs-Str. 6, D-35033, Marburg, Germany. hinneya@post.med.uni-marburg.de

European Journal of Pharmacology
|January 3, 2001
PubMed
Summary
This summary is machine-generated.

Genetic studies explore the biological underpinnings of anorexia nervosa and bulimia nervosa. Current research investigates gene variations, particularly in the serotonin system, to identify causes of these eating disorders.

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04:19

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Area of Science:

  • Psychiatry
  • Genetics
  • Neuroscience

Background:

  • Anorexia nervosa and bulimia nervosa are complex eating disorders with disturbed attitudes towards weight and body shape.
  • Genetic factors, neurotransmitter systems, and personality traits are implicated in their etiology.
  • Previous candidate gene studies have yielded inconsistent results.

Purpose of the Study:

  • To review the current understanding of genetic influences on anorexia nervosa and bulimia nervosa.
  • To evaluate the evidence for specific gene associations, such as the 5-HT(2A) gene polymorphism.
  • To highlight the need for further genetic research, including genome-wide screenings.

Main Methods:

  • Review of genetic association and transmission disequilibrium studies on candidate genes.
  • Analysis of studies focusing on the serotonergic system and body weight regulation genes.
  • Mention of ongoing large-scale genetic studies and meta-analyses.

Main Results:

  • Most candidate gene studies have produced negative or inconclusive results.
  • An association between the 5-HT(2A) gene promoter polymorphism (-1438 G/A) and anorexia nervosa has been suggested but not consistently confirmed.
  • Meta-analyses have not supported this association.

Conclusions:

  • Candidate gene approaches have not definitively identified susceptibility genes for eating disorders.
  • Genome-wide screenings are necessary to discover novel genes involved in anorexia nervosa and bulimia nervosa.
  • Continued genetic research may lead to new pharmacological treatments for eating disorders.