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Related Experiment Videos

The Ran-GTPase and cell-cycle control.

J D Moore1

  • 1Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, EN6 3LD, United Kingdom. Jonathan.Moore@icrf.icnet.uk

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 3, 2001
PubMed
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RCC1, a guanine-nucleotide exchange factor (GEF), is vital for cell cycle control and mitosis. Perturbing the Ran system disrupts DNA replication, chromosome segregation, and nuclear envelope formation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • RCC1 (guanine-nucleotide exchange factor) regulates the Ran GTPase, crucial for cell cycle progression.
  • The Ran system is implicated in nucleocytoplasmic transport, mitosis, and nuclear envelope dynamics.
  • Defects in the Ran system disrupt DNA replication, chromosome segregation, and cell cycle control.

Purpose of the Study:

  • To investigate whether cell cycle defects caused by Ran system perturbation stem from disruptions in nucleocytoplasmic transport, mitosis, or nuclear envelope regeneration.
  • Focus on vertebrate systems to understand the role of Ran in cell cycle control.

Main Methods:

  • Review and analysis of existing literature on RCC1 and the Ran GTPase network.
  • Examination of cell cycle processes including DNA replication, mitosis, and nuclear envelope formation in vertebrate cells.

Related Experiment Videos

  • Correlation of defects in these processes with perturbations in the Ran system.

    • Main Results:

    • RCC1 is essential for coordinating mitosis with S-phase completion.
    • Ran GTPase network disruptions affect DNA replication, mitotic exit, and chromosome segregation.
    • RanGTP acts as a positional flag for nuclear transport and influences microtubule polymerization near chromosomes.
    • Ran is critical for nuclear envelope regeneration post-mitosis.

    Conclusions:

    • Cell cycle progression problems induced by Ran system perturbation can be attributed to defects in nucleocytoplasmic transport, mitotic regulation, and nuclear envelope reformation.
    • The Ran system plays multifaceted roles in maintaining genomic integrity and cell division accuracy.