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Updated: Aug 13, 2026

Engineered Vascularized Muscle Flap
Published on: January 11, 2016
Microvascular reconstruction of the lower extremity
1Division of Plastic and Reconstructive Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. michael.zenn@duke.edu
Abstract:
Microvascular reconstruction has revolutionized the care of the lower extremity oncology patient. Radical limb-sparing surgeries may now be performed with the reconstructive option of unlimited transfer of tissues from elsewhere in the body. In its infancy, free tissue transfer provided vascularized tissue for wound closure. Experience with microsurgery and creative thinking have now combined to address limb function and aesthetics. In oncologic surgery, limb salvage of a functional lower extremity is currently the rule, not the exception. Semin. Surg. Oncol. 19:272-281, 2000.
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