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Updated: Jul 25, 2026

Bone Marrow-derived Macrophage Production
Published on: November 22, 2013
Bipotential B-macrophage progenitors are present in adult bone marrow
E Montecino-Rodriguez1, H Leathers, K Dorshkind
1Department of Pathology and Laboratory Medicine and the Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90095-1732, USA.
Abstract:
According to the current model of adult hematopoiesis, differentiation of pluripotential hematopoietic stem cells into common myeloid- and lymphoid-committed progenitors establishes an early separation between the myeloid and lymphoid lineages. This report describes a rare and previously unidentified CD45R-CD19+ B cell progenitor population in postnatal bone marrow that can also generate macrophages. In addition to the definition of this B-lineage intermediate, the data indicate that a developmental relationship between the B and macrophage lineages is retained during postnatal hematopoiesis.
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