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Updated: Jul 10, 2026
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Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier
Published on: November 12, 2013
Is tissue plasminogen activator a threat to neurons?
1Department of Pharmacology, Emory University, Atlanta, Georgia, USA. strayne@emory.edu
Nature Medicine
|January 3, 2001
Abstract:
The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke.
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