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Published on: August 7, 2012
[Protective effect of L-arginine on liver during ischemia-reperfusion injury]
Objective:
To explore the protective effect of L-arginine (L-Arg) on liver during hepatic ischemia-reperfusion injury (HIRI) and its mechanisms.
Methods:
Changes of several parameters, including nitric oxide (NO), malondiadehyde (MDA), thromboxane B(2) ( TXB(2) ), 6-keto-prostaglandin F(1-alpha) (6-keto-PGF(1-alpha) ), TXB(2) / 6-keto-PGF(1-alpha) ( T / K ) and alanine aminotransferase (ALT) as well as liver morphological changes, and the effect of L-Arg on them were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery.
Results:
The levels of NO and 6-keto-PGF(1-alpha) decreased remarkably. MDA concentration, TXB(2) content and T / K ratio as well as ALT activity increased significantly. The morphological changes of hepatocytes were obvious during HIRI. After treatment with L-Arg, the variations of all the parameters were markedly alleviated.
Conclusion:
L-Arg possess preventive effects on HIRI by raising NO and reducing MDA as well as correcting TXA(2) / PGI(2) imbalance after hepatic ischemia-reperfusion.
