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Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis

R T Aquino1, P P Chieffi, S M Catunda

  • 1Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, 01277-900, Brasil.

Revista Do Instituto De Medicina Tropical De Sao Paulo
|January 3, 2001
PubMed

Insights

Hepatitis B and C virus co-infection is frequent in hepatosplenic schistosomiasis patients, leading to more frequent liver decompensation. This study highlights the impact of viral co-infections in this population.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Parasitology

Background:

  • Hepatosplenic schistosomiasis (HSS) is a chronic parasitic disease.
  • Co-infections with hepatitis B (HBV) and C (HCV) viruses are common in endemic areas.
  • The impact of HBV and HCV co-infection on HSS progression is not fully understood.

Purpose of the Study:

  • To determine the prevalence of HBV and HCV co-infection in patients with HSS.
  • To investigate the clinical consequences of HBV and HCV co-infection in HSS patients.

Main Methods:

  • Serological markers for HBV and HCV were assessed in 101 HSS patients.
  • Risk factors, biochemical assays, endoscopy, and ultrasonography were evaluated.
  • PCR and histopathology were used when available.

Main Results:

  • Hepatitis B virus (HBV) markers were found in 15.8% and anti-HCV in 12.9% of patients.
  • Viral activity was demonstrated in most anti-HCV positive patients.
  • Co-infected patients showed higher liver enzyme levels, more frequent liver decompensation, and chronic hepatitis.

Conclusions:

  • The prevalence of HBV and HCV markers is elevated in HSS patients compared to controls.
  • HBV and HCV co-infection significantly increases the risk of liver decompensation in HSS.
Abstract

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