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Related Experiment Videos

Ocular involvement in systemic toxoplasmosis: a case report.

M G Sasaki1, J Arana, A G Leite

  • 1Federal University of Paraná, Clinical Hospital, Curitiba, Paraná, Brazil.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|January 3, 2001
PubMed
Summary

Adult acquired toxoplasmosis can cause ocular disease, even in immunocompetent individuals. This case highlights retinochoroiditis in a young woman with co-infection of cytomegalovirus (CMV).

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Immunology

Background:

  • Toxoplasmosis is a global protozoan infection, a leading cause of infectious retinochoroiditis in healthy individuals.
  • Acquired toxoplasmosis in immunocompetent adults is often asymptomatic or presents with lymphadenopathy.
  • Ocular manifestations are common in congenital toxoplasmosis but rare as the sole presentation of acquired disease.

Observation:

  • A 29-year-old immunocompetent female presented with a 3-week illness including lymphadenopathy, malaise, and rash, diagnosed as toxoplasmosis.
  • At diagnosis, she developed retinochoroiditis, with serologic evidence of both recent toxoplasma and cytomegalovirus (CMV) infection.
  • The patient received treatment with pyrimethamine, sulfadiazine, folic acid, and prednisone, leading to resolution of symptoms.

Findings:

Related Experiment Videos

  • This case demonstrates adult acquired toxoplasmosis presenting with significant ocular involvement (retinochoroiditis).
  • The co-occurrence of toxoplasmosis and cytomegalovirus (CMV) infection was noted in this immunocompetent patient.
  • Treatment with antiparasitic and anti-inflammatory medications resulted in a favorable clinical outcome.

Implications:

  • Ocular involvement can be a rare but serious manifestation of acquired toxoplasmosis in immunocompetent adults.
  • Concomitant viral infections, such as CMV, may play a role in the pathogenesis of ocular toxoplasmosis.
  • Prompt diagnosis and appropriate treatment are crucial for managing ocular toxoplasmosis and preventing vision loss.