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Published on: February 1, 2017

Infant and adolescent hepatitis B immunization up to 1999: a global overview

R E Vryheid, M A Kane, N Muller

    Vaccine
    |January 4, 2001
    PubMed

    Insights

    Global hepatitis B immunization programs vary by region, with high coverage in endemic areas but challenges in vaccine affordability. Universal strategies reduce disease, yet most infants remain unvaccinated, necessitating improved delivery and financing.

    Area of Science:

    • Public Health
    • Infectious Disease Epidemiology
    • Vaccinology

    Background:

    • Hepatitis B virus (HBV) infection poses a significant global health burden, particularly in endemic regions.
    • Infant and adolescent immunization are critical strategies for controlling HBV transmission and long-term sequelae.
    • Understanding global immunization program patterns is essential for targeted public health interventions.

    Purpose of the Study:

    • To provide a comprehensive global overview of hepatitis B infant and adolescent immunization programs.
    • To analyze factors influencing the implementation and coverage of these programs worldwide.
    • To identify challenges and propose strategies for increasing global hepatitis B vaccination rates.

    Main Methods:

    • Analysis of reported universal infant or adolescent immunization programs (n=108) and national infant coverage rates (n=87).
    • Correlation of program data with hepatitis B endemicity, national prosperity, policy emphasis, and immunization program strength.
    • Geographical mapping and comparative analysis of vaccination strategies across different global regions.

    Main Results:

    • Hepatitis B immunization coverage varies globally, generally correlating with regional endemicity, economic status, and policy focus.
    • High coverage (65-100%) is observed in many East/Southeast Asian, Pacific, Middle Eastern, and some European countries.
    • Despite proven effectiveness, many countries face challenges affording the vaccine, leading to low global infant immunization rates.

    Conclusions:

    • Universal hepatitis B immunization programs have successfully reduced disease incidence and prevalence, demonstrating cost-effectiveness.
    • Significant barriers remain, including vaccine affordability and logistical challenges in reaching all infants globally.
    • Future strategies may involve heat-stable vaccines, innovative financing, and multivalent vaccines to improve global coverage and reduce hepatitis B burden.

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