Effects of omeprazole on ethanol lesions

Male Sprague-Dawley rats were used to study the effects of omeprazole on normal and ethanol damaged gastric mucosa, and to estimate plasma gastrin levels following the administration of omeprazole for 2 weeks. The dosage of omeprazole was 50 mg/kg body weight, once daily via gavage. In omeprazole treated animals, serum gastrin levels showed statistically significant increases compared with the control and ethanol treated animals. Our results indicate that omeprazole has no protective effect on ethanol-induced alterations in gastric mucosa and, in fact, appears to produce worsened lesions. In achlorohydric doses, omeprazole can induce significant gastrin levels with consequent hypertrophy and hyperplasia of enterochromaffin-like cells and somatostatin cells. It is believed that this powerful drug should be reserved for patients who are refractory to standard H(2)-receptor antagonist therapy.