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Stability of monoHER in an aqueous formulation for i.v. administration
M A Abou El Hassan1, D J Touw, A J Wilhelm
1Department of Medical Oncology, Free University Hospital, P. O. Box 7057, 1007 MB, Amsterdam, The Netherlands. m.abulhassan@azvu.nl
International Journal of Pharmaceutics
|January 4, 2001
Abstract:
MonoHER is a semisynthetic flavonoid used successfully in modulating the cardiotoxic effect of doxorubicin but not its antitumor activity. The oral bioavailability of monoHER is <1%. Therefore, it should be prepared as an i.v. formulation for use in clinical trials. The solubility of monoHER in water is highly pH dependent. At pH