Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does genomic imprinting contribute to valproic acid teratogenicity?

S L Beck1

  • 1Biology Department, DePaul University, 2325 N Clifton Avenue, 60614, Chicago, IL, USA. sbeck@condor.depaul.edu

Reproductive Toxicology (Elmsford, N.Y.)
|January 4, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The preclinical toxicology of salmeterol hydroxynaphthoate.

Human & experimental toxicology·2010
Same author

Determinants of functional performance in long-term survivors of allogeneic hematopoietic stem cell transplantation with chronic graft-versus-host disease (cGVHD).

Bone marrow transplantation·2009
Same author

Caffeine decreases the occurrence of cadmium-induced forelimb ectrodactyly in C57BL/6J mice.

Teratology·2000
Same author

Psychometric testing of fatigue instruments for use with cancer patients.

Nursing research·2000
Same author

An ethnographic study of factors influencing cancer pain management in South Africa.

Cancer nursing·2000
Same author

Folinic acid reduces cleft lip [CL(P)] in A/WySn mice.

Teratology·1999
Same journal

Gadolinium Induces Sertoli Cell Damage: Cellular and Molecular Mechanisms.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same journal

Influence of radiofrequency electromagnetic radiation on spermatogenesis and sperm function in rodent models: A systematic review.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same journal

Microplastics as trojan horses: A new perspective on bisphenol toxicity in male infertility and assisted reproduction.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same journal

Effects of prenatal pyrethroid pesticides exposure on neurodevelopment of 3-year-old children: A birth cohort study in rural Southwest China.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same journal

CBD-rich oil nanoemulsion mitigates long-term testicular and endocrine toxicity induced by prenatal valproic acid exposure in rats.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same journal

Effect of cadmium exposure on ovarian abnormalities.

Reproductive toxicology (Elmsford, N.Y.)·2026
See all related articles

Genomic imprinting influences valproic acid (VPA) teratogenicity in mice. Offspring susceptibility to VPA effects, like birth defects and fetal weight, depends on parental imprinting patterns, not just direct exposure.

Area of Science:

  • Developmental biology
  • Genetics
  • Toxicology

Background:

  • Valproic acid (VPA) is a known teratogen, causing birth defects.
  • Genomic imprinting, a phenomenon of parent-specific gene expression, may influence VPA susceptibility.
  • Mouse strains exhibit varying susceptibility to VPA-induced teratogenicity.

Purpose of the Study:

  • To investigate the role of genomic imprinting in VPA teratogenicity.
  • To determine if parental origin influences offspring susceptibility to VPA.
  • To analyze the effects of VPA on fetal development, mortality, and weight in relation to imprinting.

Main Methods:

  • Reciprocal crosses and backcrosses between VPA-resistant (C57BL/6J) and VPA-susceptible (SWV) mouse strains.
  • Administration of a teratogenic dose of VPA to pregnant dams during gestation.

Related Experiment Videos

  • Examination of fetuses for abnormalities (exencephaly), mortality, litter size, and weight at gestation day 18.

    • Main Results:

    • Significant differences in exencephaly frequency were observed in backcrosses, consistent with genomic imprinting.
    • Prenatal mortality patterns also supported the role of imprinting, particularly in crosses involving SWV dams.
    • Fetal weight reduction in backcrosses involving SWV mice indicated imprinting effects.
    • Three out of four investigated parameters showed results consistent with genomic imprinting.

    Conclusions:

    • Genomic imprinting plays a significant role in modulating susceptibility to valproic acid teratogenicity.
    • Parental imprinting patterns, rather than direct maternal or paternal exposure alone, can predict offspring susceptibility to VPA.
    • These findings highlight the complex genetic and epigenetic mechanisms underlying VPA-induced developmental toxicity.