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Preimplantation exposure to bisphenol A advances postnatal development.
Y Takai1, O Tsutsumi, Y Ikezuki
1Department of Obstetrics and Gynecology, Mejirodai Campus, Faculty of Medicine, University of Tokyo, Mejirodai, Bunkyo-ku, 112-8688, Tokyo, Japan.
Reproductive Toxicology (Elmsford, N.Y.)
|January 4, 2001
Summary
Low-dose prenatal exposure to bisphenol A (BPA) enhanced early embryonic development in mice. However, BPA exposure led to heavier pups at weaning, suggesting long-term effects on postnatal development.
Area of Science:
- Endocrinology
- Developmental Biology
- Environmental Health
Background:
- Bisphenol A (BPA) is an estrogenic compound with known effects on development.
- Environmentally relevant low doses of BPA may impact development.
- Preimplantation exposure is a critical window for developmental effects.
Purpose of the Study:
- To investigate the low-dose effects of preimplantation exposure to BPA on mouse embryonic development.
- To determine if early BPA exposure influences postnatal growth and development.
Main Methods:
- Mouse embryos at the two-cell stage were cultured with 1 nM BPA.
- Embryo development to the blastocyst stage was assessed.
- BPA-exposed and control blastocysts were transferred to pseudopregnant recipients; offspring were weighed at birth and weaning.
Main Results:
- More embryos exposed to 1 nM BPA reached the blastocyst stage compared to controls.
- No significant differences in pup number or birth weight were observed between groups.
- Pups exposed to BPA preimplantation were significantly heavier at postnatal day 21 (weaning).
Conclusions:
- BPA exposure during preimplantation can affect early embryonic development even at low, environmentally relevant doses.
- Preimplantation BPA exposure can lead to late-onset effects on postnatal development, specifically increased body weight.