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Updated: Aug 15, 2026
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection
E Koutsilieri1, C Scheller, S Sopper
1Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Füchsleinstr. 15, 97080, Würzburg, Germany. eleni.koutsilieri@gmx.de
Abstract:
Human immunodeficiency virus (HIV) infection is associated with a progressive dementia, in addition to motor and behavioural deficits. Cognitive deterioration and motor impairments have been observed also in simian immunodeficiency virus (SIV)-infected monkeys, an animal model for HIV infection. We found recently that choline acetyltransferase activity is markedly reduced in brains of SIV-infected monkeys. We report now that selegiline, completely restores the reduced choline acetyltransferase activity which encourages for a meaningful anti-dementia therapeutic strategy.
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