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Related Experiment Videos

Transcriptional regulation and function during the human cell cycle.

R J Cho1, M Huang, M J Campbell

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.

Nature Genetics
|January 4, 2001
PubMed
Summary

Researchers profiled human fibroblast cell cycles, identifying ~700 genes with cell-cycle-dependent expression. This reveals coordinated gene regulation for cell division, motility, and DNA damage response, uncovering functions for uncharacterized genes.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Cell Biology

Background:

  • Understanding cell cycle regulation is crucial for comprehending cell proliferation and disease.
  • Genome-wide transcriptional analysis provides insights into complex biological processes.

Purpose of the Study:

  • To perform genome-wide transcriptional profiling of the cell cycle in human fibroblasts.
  • To identify and functionally categorize genes regulated throughout the cell cycle.

Main Methods:

  • Genome-wide transcriptional profiling of human fibroblasts.
  • Identification of genes exhibiting cell-cycle-dependent periodicity.
  • Systematic analysis of coregulated gene clusters.

Main Results:

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  • Approximately 700 genes showed cell-cycle-dependent transcriptional fluctuations.
  • Identified functional organization within coregulated gene groups.
  • Observed cell-cycle-dependent regulation of cytoskeletal genes, cell motility, and extracellular matrix remodeling genes.
  • Found overlap between S-phase upregulated genes and DNA damage-induced genes.

    • Conclusions:

    • Cell cycle progression involves coordinated regulation of diverse biological pathways, including cytoskeletal reorganization and cell motility.
    • Cell-cycle-regulated transcripts may represent coherent programs responding to stimuli like DNA damage.
    • The study provides functional insights into hundreds of previously uncharacterized human genes.