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Related Experiment Videos

Poor correlation between body surface area and glomerular filtration rate.

M J Dooley1, S G Poole

  • 1Pharmacy Department, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia. mdooley@petermac.unimelb.edu.au

Cancer Chemotherapy and Pharmacology
|January 4, 2001
PubMed
Summary

This study found a weak correlation between body surface area (BSA) and glomerular filtration rate (GFR) in cancer patients. BSA is not a reliable predictor of GFR in this population.

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Area of Science:

  • Nephrology
  • Nuclear Medicine
  • Oncology

Background:

  • Glomerular filtration rate (GFR) is a key indicator of kidney function.
  • Body surface area (BSA) is often used to normalize physiological measurements, but its utility in predicting GFR requires investigation.
  • Accurate GFR assessment is crucial in cancer patients for treatment planning and management.

Purpose of the Study:

  • To evaluate the correlation between body surface area (BSA) and glomerular filtration rate (GFR) in adult cancer patients.
  • To determine if BSA, calculated using actual or ideal body weight, can reliably estimate GFR measured by Tc-99m DTPA clearance.

Main Methods:

  • GFR was measured using Tc-99m DTPA clearance in 122 adult cancer patients.
  • Body weight (actual and ideal) and height were measured.

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  • BSA was calculated using the Du Bois and Du Bois linear method.

    • Main Results:

    • The mean GFR was 87 ml/min.
    • The mean BSA using actual weight was 1.76 m², and using ideal weight was 1.63 m².
    • A poor overall correlation was observed between BSA and GFR (r=0.24 for actual weight, r=0.22 for ideal weight), with a 95% confidence interval of 0.06-0.4.

    Conclusions:

    • There is a poor correlation between GFR measured by Tc-99m DTPA clearance and BSA calculated using the Du Bois and Du Bois method in adult cancer patients.
    • BSA is unlikely to be a clinically applicable tool for estimating GFR in this patient group.