Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Experimental neurogenic bladder disorder in non-human primates.

G F Murnaghan, S Gowland, M Rose

Transactions of the American Association of Genito-Urinary Surgeons

|January 1, 1978

Summary

The Macaca nemestrina monkey is a suitable model for studying micturition. This research validates neurogenic bladder classifications and reveals dual urethral innervation mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The prevalence and distribution of Mycobacterium bovis infection in European badgers (Meles meles) as determined by enhanced post mortem examination and bacteriological culture.

Research in veterinary science·2009

Same author

Effects of estrogen therapy on age-related differences in gray matter concentration.

Climacteric : the journal of the International Menopause Society·2009

Same author

Neuroleptics in the treatment of aggressive challenging behaviour for people with intellectual disabilities: a randomised controlled trial (NACHBID).

Health technology assessment (Winchester, England)·2009

Same author

Entire genome sequences of two new HCV subtypes, 6r and 6s, and characterization of unique HVR1 variation patterns within genotype 6.

Journal of viral hepatitis·2009

Same author

The origin and regulation of posterior pituitary vasopressin ribonucleic Acid in osmotically stimulated rats.

Journal of neuroendocrinology·2009

Same author

Differential use of 3'poly(a) addition sites in vasoactive intestinal Peptide messenger ribonucleic Acid of the rat anterior pituitary gland.

Journal of neuroendocrinology·2009

Area of Science:

Neuroscience
Urology
Animal Models

Background:

Understanding the neurological control of micturition is crucial for diagnosing and treating bladder dysfunction.
The Macaca nemestrina monkey has been proposed as a potential model for studying human urological functions.

Purpose of the Study:

To evaluate the Macaca nemestrina monkey as a model for studying the neurological mechanisms of micturition.
To validate classifications of neurogenic bladder disorders based on spinal cord and cauda equina sections.
To investigate the role of urethral innervation in maintaining urethral pressure.

Main Methods:

Surgical sectioning of the spinal cord (suprasacral) and cauda equina in Macaca nemestrina monkeys.
Assessment of bladder tonus and contractility following surgical interventions.
Evaluation of urethral pressure profiles and the influence of alpha adrenergic receptors and somatic neural control.

Main Results:

Macaca nemestrina monkeys exhibit a sacral spinal center for micturition, supporting the classification of neurogenic disorders.
Cauda equina section resulted in increased bladder tonus, not decreased, even with urinary diversion.
The monkey urethra demonstrates dual innervation involving alpha adrenergic receptors and somatic neural control, preserving resting pressure after certain lesions but reducing it after bladder overstretch.

Conclusions:

The Macaca nemestrina monkey serves as a valid model for investigating the neurological basis of micturition and neurogenic bladder disorders.
Bladder overstretch in the autonomous state does not necessarily lead to loss of tonus, but survival times were limited.
The dual innervation of the mid-urethra plays a significant role in maintaining urethral pressure, with implications for continence mechanisms.

Related Experiment Videos