Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bladder diverticulum simulating a pelvic metastasis on a Tc-99m HDP bone scan.

K D Farmer1, L R Gellett, G C Vivian

  • 1Department of Radiology, Derriford Hospital, Plymouth, Devon, United Kingdom. kimfarmer8@hotmail.com

Clinical Nuclear Medicine
|January 4, 2001
PubMed
Summary

A bone scan for prostate cancer staging revealed a false positive due to a bladder diverticulum retaining radioactive tracer. This highlights the importance of correlating imaging findings with anatomical structures for accurate diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased survival with mechanical ventilation in posttuberculosis patients with combination of respiratory failure and chest wall deformity.

Revista portuguesa de pneumologia·2015
Same author

Stool submission data to help inform population-level incidence rates of enteric disease in a Canadian community.

Epidemiology and infection·2014
Same author

Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA(2)LEN survey.

Allergy·2012
Same author

Medico-legal implications of sleep apnoea syndrome: driving license regulations in Europe.

Sleep medicine·2007
Same author

Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey.

Thorax·2005
Same author

Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms.

The European respiratory journal·2004

Area of Science:

  • Nuclear medicine imaging
  • Urologic oncology
  • Radiology

Background:

  • Prostate carcinoma diagnosis and staging are crucial for treatment planning.
  • Bone scintigraphy using Technetium-99m hydroxymethylene diphosphonate (Tc-99m HDP) is a standard imaging modality for detecting bone metastases.
  • Interpreting bone scan findings requires careful consideration of potential artifacts and non-osseous uptake.

Observation:

  • A 74-year-old man diagnosed with prostate carcinoma underwent Tc-99m HDP bone scan for staging.
  • The bone scan demonstrated an area of increased tracer uptake over the left sacroiliac joint, initially concerning for metastatic disease.
  • Radiographs were inconclusive, necessitating further investigation.

Findings:

  • Computed tomography (CT) revealed a large diverticulum of the urinary bladder on the left side.

Related Experiment Videos

  • The increased tracer uptake on the bone scan was attributed to Tc-99m HDP retained within this bladder diverticulum.
  • This finding represents a false positive on bone scintigraphy.

    • Implications:

    • Bladder diverticula can cause false-positive findings on bone scans due to tracer accumulation.
    • Accurate interpretation of bone scintigraphy necessitates correlation with cross-sectional imaging like CT to identify anatomical variants and artifacts.
    • Understanding potential sources of aberrant tracer uptake is essential for precise staging of prostate carcinoma and avoiding unnecessary interventions.