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A narrow QRS does not predict a normal left ventricular function in Chagas' disease.

A L Ribeiro1, M O Rocha, M V Barros

  • 1Hospital das Clínicas, and School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. antonior@net.em.com.br

Pacing and Clinical Electrophysiology : PACE
|January 5, 2001
PubMed
Summary

A narrow QRS duration on ECG does not rule out left ventricular systolic dysfunction in Chagas disease patients. Further evaluation is needed as abnormalities impact prognosis and treatment.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Echocardiography

Background:

  • Left ventricular (LV) systolic dysfunction is a key prognostic factor in Chagas' disease (ChD).
  • Reliable screening for LV dysfunction is crucial for managing ChD patients.
  • Previous studies suggested QRS duration predicts LV dysfunction.

Purpose of the Study:

  • To assess the relationship between QRS duration and LV function in ChD patients.
  • To determine if a narrow QRS on ECG predicts normal LV function.

Main Methods:

  • Ninety-eight ChD patients underwent ECG and Doppler echocardiography.
  • QRS duration was manually measured by a blinded investigator.
  • LV dysfunction was defined by LV dilatation, reduced ejection fraction, contractile abnormalities, or aneurysm.

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Main Results:

  • QRS duration correlated significantly with LV diastolic dimension and ejection fraction.
  • A notable percentage of patients with narrow QRS (<100 ms) showed LV dilatation, reduced EF, SCA, and LV aneurysm.
  • A narrow QRS did not exclude global or segmental LV dysfunction.

Conclusions:

  • A narrow QRS duration on surface ECG does not exclude significant LV systolic dysfunction in ChD.
  • Further evaluation of LV systolic performance is recommended for ChD patients.
  • LV dysfunction has prognostic and therapeutic implications in Chagas' disease.