Related Experiment Video
Updated: Aug 16, 2026

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
Published on: December 18, 2014
Memory effects of the Ca2+ and 5-HT antagonists dotarizine and flunarizine
V D Petkov1, E Konstantinova, V V Petkov
1Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Abstract:
In experiments on Wistar and Long Evans rats, using behavioral methods for passive (step-down and step-through) and active (shuttle-box two-way avoidance with punishment reinforcement) the newly synthesized diphenyl-methyl-piperazine derivative with Ca2+ and 5-HT antagonistic action dotarizine (DOT) administered repeatedly at oral doses of 50 and 10 mg/kg in some cases improve memory process. Under the same experimental conditions the chemically related to dotarizine Ca2+ antagonist flunarizine significantly facilitated retention. In old (Long Evans and Wistar) rats DOT in large dose decreases values of learning criterion. Probably this is a manifestation of the inherent to drugs with nootropic action "therapeutic window". Earlier investigations of the same and other authors suggest the participation of serotonergic neurotransmission in the mechanism of the memory effects of the drug DOT.
More Related Videos
Related Concept Videos
Desensitization and Tachyphylaxis
Several...
Antipsychotic Drugs: Typical and Atypical Agents
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

