Antioxidant activity of parapharmaceutics containing natural inhibitors of free radical processes
G G Konovalova1, A K Tikhaze, V Z Lankin
1Laboratory of Biochemistry of Free Radical Processes, AL Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Center, Russian Ministry of Health, Moscow.
Abstract:
The duration of lag phase of ascorbate-dependent free radical oxidation of endogenous polyenic lipids in rat liver and myocardium considerably increased after oral administration of lacrinat containing licorice Glycyrrhiza glabra root powder for 1 month. Lacrinat markedly decreased the content of lipid peroxides in rat liver. Ex vivo antioxidant effects of lacrinat in rat liver were comparable with those of beta-carotene-containing preparations carinat and carinat CD. Parapharmaceutics containing both licorice Glycyrrhiza glabra root powder and beta-carotene (carinat forte) markedly increased antioxidant activity of the liver.
Related Concept Videos
Feedback Inhibition
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Drugs Affecting Neurotransmitter Synthesis
Bioactivation and Tissue Toxicity


