Toxic epidermal necrolysis in a monkey (Macaca fascicularis)

Area of Science:

• Toxicology
• Dermatology
• Primate Research

Background:

• Methylmercury is a potent neurotoxin with known systemic effects.
• Toxic epidermal necrolysis (TEN) is a severe, life-threatening mucocutaneous reaction.

Observation:

• An adult male crab-eating macaque (Macaca fascicularis) ingested methylmercury.
• The monkey subsequently developed clinical signs consistent with toxic epidermal necrolysis.

Findings:

• Characterized by large cutaneous bullae and full-thickness epidermal exfoliation.
• Affected areas included sparse pelage regions, palms, soles, face, and ears.
• Mucosal erosions were observed in the oral cavity and conjunctivae.

Implications:

• This case highlights methylmercury as a potential inducer of toxic epidermal necrolysis in non-human primates.
• Provides a model for studying methylmercury toxicity and severe cutaneous adverse reactions.
• Underscores the importance of environmental toxin monitoring in animal health and human safety.