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Updated: Oct 10, 2026

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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Nitroimidazoles and hypoxia imaging: synthesis of three technetium-99m complexes bearing a nitroimidazole group:
F Riché1, A D d'Hardemare, S Sèpe
1Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Université Joseph Fourier, UMR 5616-BP 53, Grenoble, France. francoise.riche@ujf-grenoble.fr
Bioorganic & Medicinal Chemistry Letters
|January 5, 2001
Abstract:
Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions.

