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Related Experiment Videos

Fibrin clot formation and lysis: basic mechanisms.

J J Sidelmann1, J Gram, J Jespersen

  • 1Department for Thrombosis Research, University of Southern Denmark, Esbjerg. jsi@ribeamt.dk

Seminars in Thrombosis and Hemostasis
|January 5, 2001
PubMed
Summary

Fibrin turnover is crucial for hemostasis. This review details fibrin formation, degradation, and factors influencing its structure, highlighting implications for thrombosis, bleeding, and disease development.

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Area of Science:

  • Biochemistry
  • Hematology
  • Molecular Biology

Background:

  • Hemostasis relies on a delicate balance of fibrin turnover.
  • Fibrin is central to this balance, with defects leading to thrombosis or bleeding.
  • Understanding fibrin formation and degradation is key to hemostasis physiology.

Purpose of the Study:

  • To review the components and processes of fibrin formation and degradation.
  • To emphasize reactions in fibrinogen-to-fibrin conversion, polymerization, and breakdown.
  • To address factors influencing fibrin structure and breakdown, including genetic polymorphisms and environmental conditions.

Main Methods:

  • Literature review of biochemical publications on fibrin turnover and structure.
  • Analysis of reactions involving fibrinogen, fibrin, coagulation factor XIII (FXIII), plasmin, and elastase.

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  • Examination of genetic polymorphisms and physical/biochemical conditions affecting fibrin.

    • Main Results:

    • Fibrinogen conversion to fibrin involves specific reactions and polymerization.
    • Fibrin degradation is mediated by plasmin and elastase.
    • Fibrin structure alterations are linked to disease, and can be modified by drugs.

    Conclusions:

    • Alterations in fibrin structure impact disease development.
    • Genetic factors (e.g., fibrinogen and FXIII polymorphisms) influence hemostatic diseases.
    • Further clinical research on fibrin metabolism, elastase, and genetic influences is warranted.