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Published on: May 29, 2016
New malyngamides from the Hawaiian cyanobacterium Lyngbya majuscula
1Suntory Institute for Bioorganic Research, Wakayamadai, Shimamoto, Mishima-gun, Osaka 618-8503, Japan. kan@sunbor.or.jp
Abstract:
Isomalyngamides A and B (1, 2) were isolated and characterized from a collection of the cyanobacterium Lyngbya majuscula from Hawaiian waters. These compounds represent a new type of malyngamide, similar to malyngamides Q and R, in which the conformation of the chloromethylene group is opposite from the majority of previously reported malyngamides. The geometry of the chloromethylene moiety was elucidated from the long-range coupling constants ((3)J(C)(-)(H)) obtained from editing-HETLOC and phase-sensitive HMBC experiments. Isomalyngamides A and B (1, 2) showed lethal toxicity to crayfish.
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