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New marine cembrane-type diterpenoids from the Okinawan soft coral Clavularia koellikeri
M Iwashima1, Y Matsumoto, H Takahashi
1Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Journal of Natural Products
|January 5, 2001
Abstract:
Seven new marine diterpenoids having a cembrane skeleton were isolated from the Okinawan soft coral Clavularia koellikeri. Their structures were determined based on the results of spectroscopic analysis and chemical conversions. Compound 1 showed cytotoxic activity against human colorectal adenocarcinoma cells (DLD-1, IC(50) 4.2 g/mL) and strong growth inhibition against human T lymphocytic leukemia cells (MOLT-4, IC(50) 0.9 g/mL).