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Two novel flavanones from Greigia sphacelata.

M L Flagg¹, G A Wächter, A L Davis

¹Department of Pharmaceutical Sciences and Department of Pharmacology and Toxicology, Division of Medicinal Chemistry, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, USA.

Journal of Natural Products

|January 5, 2001

Summary

Phytochemical analysis of Greigia sphacelata from Chile revealed two new flavanones. Further investigation identified eight known compounds, expanding our knowledge of arid plant chemistry.

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Area of Science:

Phytochemistry
Natural Product Chemistry
Botany

Background:

Phytochemical investigations are crucial for discovering novel bioactive compounds.
Plants from arid environments often possess unique chemical defenses.
Greigia sphacelata is a plant species found in Chilean arid regions.

Purpose of the Study:

To conduct phytochemical investigations of Greigia sphacelata aerial parts.
To isolate and identify novel and known chemical compounds from the plant.
To contribute to the understanding of the chemical constituents of arid-adapted flora.

Main Methods:

Phytochemical analysis of Greigia sphacelata aerial parts.
Isolation of chemical compounds using chromatographic techniques.

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Structure elucidation of isolated compounds using spectroscopic methods.

Main Results:

Two novel flavanones were isolated and characterized: 5,7,3'-trihydroxy-6,4',5'-trimethoxyflavanone and 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavanone.
Eight known compounds were also identified: 1,3-O-di-trans-p-coumaroylglycerol, 1-O-trans-p-coumaroylglycerol, a mixture of 1-(omega-feruloyldocosanoyl)glycerol and 1-(omega-feruloyltetracosanoyl)glycerol, trans-ferulic acid 22-hydroxydocosanoic acid ester, arborinone, arborinol, and isoarborinol.
The study expands the known phytochemical profile of Greigia sphacelata.

Conclusions:

The phytochemical investigation of Greigia sphacelata led to the discovery of new flavanones.
The identified compounds contribute to the chemical diversity known in plants from arid environments.
This research enhances the understanding of Greigia sphacelata's chemical constituents.