Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspectives: does amiodarone increase non-sudden deaths? If so, why?

A Auricchio1, S Nisam, H U Klein

  • 1Department of Cardiology, University Hospital, Magdeburg, Germany. angelo.auricchio@medizin.uni-magdeburg.de

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|January 5, 2001
PubMed
Summary

Amiodarone effectively treats arrhythmias but may increase non-arrhythmic deaths in heart failure patients. This study explores how amiodarone

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Dynamic imaging" (systolic compression) of myocardial bridge visualised by electronic beam computed tomography.

BMJ case reports·2025
Same author

Candidacy and long-term outcomes of subcutaneous implantable cardioverter-defibrillators in current practice in patients with hypertrophic cardiomyopathy.

International journal of cardiology·2024
Same author

Reporting standard for describing first responder systems, smartphone alerting systems, and AED networks.

Resuscitation·2023
Same author

Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy.

International journal of cardiology·2019
Same author

A statistical shape model of the left ventricle from real-time 3D echocardiography and its application to myocardial segmentation of cardiac magnetic resonance images.

Computers in biology and medicine·2018
Same author

Fast uncertainty quantification of activation sequences in patient-specific cardiac electrophysiology meeting clinical time constraints.

International journal for numerical methods in biomedical engineering·2018

Area of Science:

  • Cardiology
  • Pharmacology
  • Heart Failure Research

Background:

  • Amiodarone is a potent antiarrhythmic drug.
  • A correlation between amiodarone and increased non-arrhythmic mortality in heart failure patients with reduced ejection fraction has been observed.
  • Cardiac resynchronization therapy research offers potential insights.

Purpose of the Study:

  • To discuss the potential link between amiodarone and non-arrhythmic mortality.
  • To hypothesize a cause-effect relationship based on amiodarone's electrophysiological properties.
  • To explore amiodarone's impact on cardiac electromechanical function.

Main Methods:

  • Literature review and theoretical discussion.
  • Analysis of amiodarone's electrophysiological effects.

Related Experiment Videos

  • Correlation with findings from cardiac resynchronization therapy studies.

    • Main Results:

    • Amiodarone's electrophysiological properties may cause cardiac electromechanical disarrangement.
    • This disarrangement is hypothesized to contribute to non-arrhythmic mortality.
    • The mechanism may involve disruption of normal cardiac electrical and mechanical coupling.

    Conclusions:

    • Amiodarone's antiarrhythmic benefits are contrasted with potential risks in heart failure.
    • Cardiac electromechanical disarrangement is a plausible mechanism linking amiodarone to increased non-arrhythmic mortality.
    • Further research is needed to confirm this hypothesis and guide clinical practice.