Related Experiment Video
Updated: Aug 9, 2026
09:13
Isolation, Transfection, and Culture of Primary Human Monocytes
Published on: December 16, 2019
Reduced reactive hyperemia in HIV-infected patients
J J Monsuez1, J Dufaux, D Vittecoq
1Department of Internal Medicine, Hôpital Paul Brousse, Villejuif, France. medint.p-brousse@pbr.ap-hop-paris.fr
Journal of Acquired Immune Deficiency Syndromes (1999)
|January 5, 2001
Summary
Human immunodeficiency virus (HIV) infection impairs vascular reactivity, particularly in patients with cardiac symptoms or hyperlipemia. This reduced blood flow response, assessed via reactive hyperemia, highlights potential cardiovascular complications in HIV patients.
Area of Science:
- Cardiovascular Research
- Infectious Diseases
- Vascular Biology
Background:
- Pathology studies indicate coronary and arterial vasculopathy in HIV-infected patients.
- This study investigates abnormal vascular reactivity in HIV patients.
Purpose of the Study:
- To assess vascular reactivity in HIV-infected patients using noninvasive laser-Doppler flow measurement.
- To compare vascular responses between symptomatic HIV patients, asymptomatic HIV patients, and healthy controls.
Main Methods:
- Laser-Doppler flowmetry measured finger-skin blood flow at baseline.
- Vascular reactivity assessed via postocclusive reactive hyperemia, acetylcholine (Ach)-induced vasodilation, and nitroglycerin-induced vasodilation.
Main Results:
- Reduced reactive hyperemia observed in asymptomatic HIV patients compared to controls (p<0.0001).
- Symptomatic HIV patients exhibited more pronounced reductions in reactive hyperemia.
- Endothelium-independent vasodilation (nitroglycerin) showed no significant differences between groups.
Conclusions:
- Postischemic reactive hyperemia is significantly reduced in HIV-infected patients.
- A trend towards reduced endothelium-dependent vasodilation (Ach) was noted in symptomatic HIV patients.
