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Related Experiment Videos

Inverse relationship between neopterin and immunoglobulin E.

M Ledochowski1, C Murr, B Widner

  • 1Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria.

Clinical Immunology (Orlando, Fla.)
|January 6, 2001
PubMed
Summary

Human immune responses involve T helper (Th) cells. This study found that increased neopterin, a marker of Th1 response, correlates with decreased immunoglobulin E (IgE), a marker of Th2 response, suggesting immune pathway interactions.

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Area of Science:

  • Immunology
  • Cellular Immunology
  • Human Immune System

Background:

  • T helper (Th) cells orchestrate specific immune responses.
  • Th1 cells drive cell-mediated immunity (interferon-gamma, interleukin-2).
  • Th2 cells drive humoral immunity (interleukin-4, -5, -10, immunoglobulin E).

Purpose of the Study:

  • To investigate the relationship between Th1 and Th2 immune stimulation.
  • To compare serum neopterin (Th1 marker) and immunoglobulin E (IgE, Th2 marker) concentrations in healthy individuals.

Main Methods:

  • Serum neopterin and IgE levels were measured in 709 healthy outpatients.
  • Spearman's rank correlation was used to analyze the relationship between neopterin and IgE.
  • Analyses were performed on the entire cohort and a subset with elevated markers.

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Main Results:

  • 11% had elevated neopterin (>8.7 nmol/L); 26% had elevated IgE (>100 kIU/L).
  • An inverse correlation was observed between serum neopterin and IgE concentrations (r(s) = -0.100, P < 0.01).
  • This inverse correlation was stronger in a subset excluding low marker values (n = 246; r(s) = -0.519, P < 0.0001).

Conclusions:

  • Increased neopterin is associated with low IgE, and increased IgE with low neopterin.
  • These findings support the concept of mutual down-regulation between human Th1 and Th2 immune responses.