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Updated: Aug 12, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
[Mutational analysis of p53 in T-cell lymphoblastic leukemia]
J F Nomdedéu1, I Badell, C Estivill
1Hematología. Hospital de la Santa Creu i Sant Pau. Barcelona. jnomdedeu@santpau.es
Background:
p53 mutations were analysed in a consecutive series of patients with T-ALL from one hospital over a period of 9 years.
Patients And Method:
Thirty two samples from 27 patients with T-ALL were included in the study. Exons 5-9 were analysed using SSCP.
Results:
A mutation at codon 273 was identified in a child in third relapse. The mutated clone became dominant in a sample obtained one month following a course of salvage chemotherapy.
Conclusion:
p53 mutations are not frequent in T-ALL even in patients at relapse.
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