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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
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Identification of a novel gene with increasing rate of suppression in high grade prostate cancers

Y P Yu1, F Lin, M Bisceglia

  • 1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

The American Journal of Pathology
|January 6, 2001
PubMed

Insights

Researchers identified a novel gene, SAPC, inactivated in aggressive prostate cancer. This gene

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a leading cause of cancer deaths in the U.S.
  • Molecular mechanisms of prostate cancer are not fully understood.

Purpose of the Study:

  • Identify novel genes involved in prostate cancer development.
  • Investigate the role of gene expression changes in high-grade prostate cancer.

Main Methods:

  • Utilized differential subtraction chain (DSC) technology.
  • Analyzed gene expression in normal, low-grade, and high-grade prostate cancer tissues.

Main Results:

  • Discovered a novel gene, SAPC, expressed in normal prostate cells.
  • Found SAPC expression dramatically down-regulated in high-grade prostate cancers.
  • Observed no change in SAPC expression in low-grade prostate cancers.

Conclusions:

  • SAPC inactivation is specific to aggressive prostate cancer.
  • SAPC may serve as a prognostic marker for high-grade prostate cancer.
  • Further research into SAPC's function in apoptosis is warranted.

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