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Cytotoxic clerodane diterpene esters from Laetia corymbulosa
J A Beutler1, K L McCall, K Herbert
1Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick Cancer Reasearch and Development Center, MD 21702-1201, USA.
Phytochemistry
|January 6, 2001
Abstract:
Three cytotoxic clerodane diterpene esters, corymbulosins A-C, were isolated from an organic extract of the fruit of Laetia corymbulosa (Flacourtiaceae) from Peru. The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14. Corymbulosin A was esterified at C-2 with a decadienoate moiety, while corymbulosins B and C were C-2 epimers esterified at C-6 with a decanoate moiety.