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Herbertane-type sesquiterpenoids from the liverwort Herbertus sakuraii
H Irita1, T Hashimoto, Y Fukuyama
1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Phytochemistry
|January 6, 2001
Summary
Researchers isolated seven novel herbertane-type sesquiterpenoids from the Japanese liverwort Herbertus sakuraii. This discovery highlights the plant
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Botany
Background:
- The Japanese liverwort Herbertus sakuraii is a source of diverse sesquiterpenoids.
- Previous research indicates chemical similarities between Herbertus species and Mastigophora species.
Purpose of the Study:
- To isolate and characterize novel sesquiterpenoids from Herbertus sakuraii.
- To investigate the chemical relationship between H. sakuraii and related species.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via comprehensive spectroscopic methods (NMR, MS).
Main Results:
- Seven new herbertane-type sesquiterpenoids were identified: 1,13-dihydroxyherbertene, 1,14-dihydroxyherbertene, 1,15-dihydroxyherbertene, 12-methoxyherbertene-1,2-diol, herberteneacetal, herbertenone A, and herbertenone B.
- Four known herbertane-type and three dimeric herbertane-type sesquiterpenoids were also isolated.
- Ent-pimara-8(14),15-dien-19-oic acid was identified.
Conclusions:
- Herbertus sakuraii possesses a unique profile of sesquiterpenoids.
- The chemical constituents of H. sakuraii support its close relationship with H. aduncus and Mastigophora species.