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Coprescribing proton pump inhibitors with other medications
1Virginia Commonwealth University, Medical College of Virginia School of Pharmacy, Richmond, Virginia, USA. wgarnett@hsc.vcu.edu
Managed Care Interface
|January 6, 2001
Summary
Proton pump inhibitors (PPIs) are common for acid-related issues but can interact with other drugs. A review found 10 specific medications with adverse interactions, highlighting the need for careful prescribing.
Area of Science:
- Pharmacology
- Gastroenterology
- Drug Interactions
Background:
- Proton pump inhibitors (PPIs) are primary treatments for acid-related gastrointestinal disorders.
- PPIs are frequently prescribed and often used concurrently with other medications.
- Potential for adverse drug interactions exists with PPI coadministration.
Purpose of the Study:
- To review documented adverse interactions between proton pump inhibitors and other commonly coadministered drugs.
- To identify specific medications with a higher risk of interaction when used with PPIs.
Main Methods:
- A literature review was conducted to identify reported adverse interactions involving PPIs.
- The review focused on medications frequently coadministered with PPIs, including other gastrointestinal agents.
Main Results:
- Adverse interactions were documented for 10 specific medications when coadministered with PPIs.
- A significant proportion of PPI users (44%) also received another gastrointestinal drug.
- While documented interactions are infrequent, the potential for problematic combinations is present.
Conclusions:
- Physicians and pharmacists must be aware of potential adverse interactions between PPIs and other medications.
- Vigilance is recommended to monitor for and manage potentially problematic combination therapies involving PPIs.