Coprescribing proton pump inhibitors with other medications

Proton pump inhibitors, the treatment of choice for acid-related disorders, are often coadministered with other medications, sometimes with potentially adverse interactions. Although all agents studied may potentially interact with one proton pump inhibitor or another, a literature review documented adverse interactions for 10 medications in particular. Furthermore, 44% of people using proton pump inhibitors received another gastrointestinal drug. Although documented interactions involving these agents have been reported infrequently, the authors advise that physicians and pharmacists should recognize this possibility and watch for potentially problematic combination therapy.