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[Carbamazepine-induced hepatitis]
J W Haukeland1, J Jahnsen, N Raknerud
1Avdeling for fordøyelsessykdommer Medisinsk klinikk, Aker Sykehus 0514 Oslo. johnwilly@os.telia.no
Background:
Hepatotoxic reactions associated with carbamazepine therapy are well recognised, and it is important that clinicians are aware of this adverse effect.
Material And Methods:
We present the clinical course in three patients with carbamazepine-induced hepatitis.
Results:
All three patients had clinical and biochemical signs of hepatitis; improvement occurred immediately after carbamazepine therapy was discontinued. Other causes of hepatitis were excluded.
Interpretation:
Previous reports concerning this adverse effect are reviewed. Focusing on the liver as the major organ for drug metabolism, we discuss possible pathophysiological mechanisms of drug-induced hepatic injury. A thorough medication history is mandatory in all patients with hepatitis and other liver diseases. The prognosis of carbamazepine-induced hepatitis is usually excellent, but fatal cases have been reported.