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Related Experiment Videos

Fever and survival.

M J Kluger, D H Ringler, M R Anver

    Science (New York, N.Y.)
    |April 11, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Fever, an elevated body temperature, significantly enhances lizard survival against bacterial infections. This study shows that a higher body temperature improves the host

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    Area of Science:

    • Comparative physiology
    • Animal models in infection research
    • Thermoregulation and immunity

    Background:

    • Fever is a common response to bacterial infections.
    • The role of fever in enhancing host resistance is not fully understood.
    • The desert iguana (Dipsosaurus dorsalis) serves as a model organism.

    Purpose of the Study:

    • To investigate the significance of fever in response to bacterial infection.
    • To determine if elevated body temperature increases host survival against Aeromonas hydrophila.
    • To assess the impact of ambient temperature on fever response and survival.

    Main Methods:

    • Experimental infection of Dipsosaurus dorsalis with Aeromonas hydrophila.
    • Exposure of infected lizards to controlled ambient temperatures (neutral, low, and high).

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  • Measurement of host survival rates at different temperatures.

    • Main Results:

    • Lizards developed a fever of approximately 2 degrees C after bacterial injection.
    • Elevated ambient temperatures led to increased host survival.
    • A significant positive correlation was observed between elevated body temperature and survival rates.

    Conclusions:

    • Fever significantly enhances host survival during bacterial infections.
    • Thermoregulation plays a crucial role in the immune response.
    • The findings support the adaptive significance of fever in combating pathogens.