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Interleukin-1 family: from genes to human disease
1Department of Immunology, Medical Faculty of Palacký University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae
|January 6, 2001
Abstract:
Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiological immune responses and in the development of various immunopathological disorders. The members of IL-1 family form a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre of research interests. This review article except of summarising recent findings about IL-1 family members focuses on associations of IL-1 gene complex polymorphisms with human diseases.