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Papillary carcinoma in amyloid goitre
A Coli1, G Bigotti, F Zucchetti
1Istituto di Anatomia Patologica, Rome, Italy.
Journal of Experimental & Clinical Cancer Research : CR
|January 6, 2001
Summary
Amyloid goitre, a rare thyroid enlargement from amyloid deposition, can rarely present with adipose tissue and thyroid carcinoma. This case highlights a unique instance of thyroid carcinoma within amyloid goitre with massive adipose metaplasia.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Amyloid goitre is a rare thyroid condition involving diffuse enlargement due to amyloid deposition.
- While uncommon, adipose tissue deposition and differentiated thyroid carcinoma can occur within amyloid goitre.
Observation:
- This report details a rare case of thyroid carcinoma in a 74-year-old female with amyloid goitre and massive adipose thyroidal metaplasia.
- Diagnosis was confirmed via Congo red stain and immunohistochemistry for amyloid fibril protein A.
- The patient had unexplained renal failure but no signs of systemic amyloidosis.
Findings:
- The coexistence of amyloid goitre, adipose metaplasia, and differentiated thyroid carcinoma is exceptionally rare.
- Immunohistochemistry confirmed amyloid fibril protein A, supporting the diagnosis.
Implications:
- Accurate diagnosis of amyloid goitre is crucial for ruling out thyroid carcinoma.
- Identifying amyloid goitre warrants investigation for systemic amyloidosis and other organ involvement for timely treatment.