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Strategies for the physiome project.

J B Bassingthwaighte1

  • 1Department of Bioengineering, University of Washington, Seattle 98195-7962, USA. jbb@bioeng.washington.edu

Annals of Biomedical Engineering
|January 6, 2001
PubMed
Summary
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The Physiome Project aims to create a virtual human by integrating structural and functional data. This initiative will enable better drug design and predict genomic intervention effectiveness.

Area of Science:

  • * Systems Biology
  • * Computational Biology
  • * Bioinformatics

Background:

  • * The physiome represents a quantitative description of an organism's functioning in health and disease.
  • * It is built upon the morphome, which details anatomical structure, composition, and material properties.
  • * The human physiome can be conceptualized as a virtual human.

Purpose of the Study:

  • * To design, develop, implement, test, document, archive, and disseminate quantitative information and integrative models of functional behavior across biological scales.
  • * To create a comprehensive understanding of biological systems from molecules to whole organisms.
  • * To establish the scientific basis for physiological genomics and its application.

Main Methods:

  • * Integrating data from diverse sources to build multi-scale models.

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  • * Developing collaborative strategies for complex, large-scale systems modeling.
  • * Utilizing bioinformatics technologies for data management and model integration.
  • * Addressing challenges in linking complex submodules while preserving mass balance and accurately representing nonlinear biochemical networks.

    • Main Results:

    • * Establishment of a framework for a virtual human (physiome).
    • * Development of integrative models for functional behavior across biological scales.
    • * Identification of critical needs for databased experimental observations, kinetics, and dynamics.
    • * Highlighting the computational challenges and the need for faster computation.

    Conclusions:

    • * Comprehensive models of biological systems are crucial for pharmaceutics and drug design.
    • * These models will improve predictions of therapeutic interventions and drug side effects.
    • * The Physiome Project is foundational for physiological genomics and the Genes to Health initiative.
    • * Accurate data on tissue composition, material properties, and mechanical behavior are essential for model development.