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New strong fibrates with piperidine moiety
T Komoto1, T K Hirota, M Otsuka
1Central Research Labs, SSP Co, Ltd, Narita, Chiba, Japan. Teruo.Komoto@ssp.co.jp
Chemical & Pharmaceutical Bulletin
|January 6, 2001
Abstract:
New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxyl-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.