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Unusual growth within a meningioma (leukemic infiltrate)
A Sonet1, J Hustin, B De Coene
1Department of Hematology, UCL Mont-Godinne University Hospital, Yvoir, Belgium.
Abstract:
Intracranial meningiomas are generally slow-growing neoplasms. Symptoms depend on their critical intracranial location. The authors describe a case of rapidly enlarging meningioma that became symptomatic as a result of invasion by leukemic cells at the time of a blastic crisis in the context of chronic myeloid leukemia. Infiltration of an intracranial meningioma by cells from extracranial malignant neoplasms is a rare event. Even though central nervous system (CNS) or meningeal involvement is common in some hematologic malignancies, this is, to the best of our knowledge, the first report of invasion of an intracranial meningioma by leukemic cells.
Insights
This study reports a rare case of an intracranial meningioma rapidly enlarging due to invasion by leukemic cells during a chronic myeloid leukemia blastic crisis. This is the first documented instance of leukemic cell infiltration into a brain tumor.
Area of Science:
- Neuro-oncology
- Hematology
- Pathology
Background:
- Intracranial meningiomas are typically slow-growing tumors.
- Symptoms of meningiomas are dictated by their location within the skull.
- Leukemic infiltration of central nervous system (CNS) or meninges is known in hematologic malignancies.
Observation:
- A case of a rapidly enlarging intracranial meningioma is presented.
- The meningioma became symptomatic due to invasion by leukemic cells.
- This occurred during a blastic crisis of chronic myeloid leukemia.
Findings:
- This is the first reported case of leukemic cells invading an intracranial meningioma.
- The event coincided with a blastic crisis in chronic myeloid leukemia.
- Infiltration by extracranial malignant neoplasms into meningiomas is exceptionally rare.
Implications:
- Highlights a rare but aggressive presentation of chronic myeloid leukemia.
- Suggests the need for vigilance regarding potential secondary tumor infiltration in hematologic malignancies.
- Expands understanding of CNS involvement in hematologic disorders.