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Anal carcinoma: a 15-year retrospective analysis.
O Olofinlade1, O Adeonigbagbe, N Gualtieri
1Dept. of Medicine, St Vincent's Hospital, New York, NY 10011, USA.
Scandinavian Journal of Gastroenterology
|January 6, 2001
Summary
Cloacogenic and squamous cell carcinoma of the anus are rare large bowel cancers. Squamous cell carcinoma is more common, affects younger individuals, and is linked to human papilloma virus (HPV) and human immune deficiency virus (HIV) infections.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Cloacogenic and squamous cell carcinoma of the anus are rare malignancies.
- This study examines their clinicopathologic, treatment, and survival characteristics.
Purpose of the Study:
- To analyze the clinicopathologic features, treatment modalities, and survival outcomes of cloacogenic and squamous cell carcinoma of the anus.
- To compare the characteristics of these two histologic variants.
Main Methods:
- Retrospective analysis of patients diagnosed with cloacogenic or squamous cell carcinoma of the anus.
- Data collected over a 15-year period from two teaching hospitals.
Main Results:
- Squamous cell carcinoma (69.6%) was more common than cloacogenic carcinoma (30.4%).
- Squamous cell carcinoma presented at a younger mean age (57 years) compared to cloacogenic carcinoma (66.3 years).
- Squamous cell carcinoma was associated with human papilloma virus (HPV) and human immune deficiency virus (HIV) infections, unlike cloacogenic carcinoma.
Conclusions:
- Cloacogenic and squamous cell carcinoma constitute a small fraction of large bowel cancers.
- Squamous cell carcinoma is more prevalent, occurs in younger patients, and is linked to HPV and HIV.
- Treatment and survival outcomes were similar for both histologic types, with female sex and disease stage being key survival factors.