Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using the COG database to improve gene recognition in complete genomes.

D A Natale1, M Y Galperin, R L Tatusov

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Healtl, Bethesda MD 20894, USA.

Genetica
|January 6, 2001
PubMed
Summary

Understanding organism biology requires knowing its genetic makeup. This study uses phylogenetic patterns from the Clusters of Orthologous Groups (COGs) database to find missing protein-coding genes in genomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermodynamic selection: mechanisms and scenarios.

New journal of physics·2023
Same author

COVID-19 Biomarkers in research: Extension of the OncoMX cancer biomarker data model to capture biomarker data from other diseases.

bioRxiv : the preprint server for biology·2020
Same author

Ancient Systems of Sodium/Potassium Homeostasis as Predecessors of Membrane Bioenergetics.

Biochemistry. Biokhimiia·2015
Same author

Microbial culturomics: paradigm shift in the human gut microbiome study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2012
Same author

The phylogenetic forest and the quest for the elusive tree of life.

Cold Spring Harbor symposia on quantitative biology·2009
Same author

Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis.

Cell death and differentiation·2009

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Understanding an organism's biology necessitates a comprehensive knowledge of its genetic makeup.
  • Identifying and characterizing proteins encoded within a genome is crucial for determining an organism's biochemical pathways and functional systems.

Purpose of the Study:

  • To present the utility of phylogenetic patterns for targeted searches of undetected protein-coding genes in complete genomes.
  • To highlight the Clusters of Orthologous Groups (COGs) database as a tool for selecting protein families based on phylogenetic patterns.

Main Methods:

  • Utilizing the Clusters of Orthologous Groups (COGs) database.
  • Employing phylogenetic patterns to represent the presence or absence of species within a COG.
  • Performing targeted searches for protein-coding genes in complete genomes based on phylogenetic patterns.

Related Experiment Videos

Main Results:

  • Demonstrated the effectiveness of phylogenetic patterns in identifying protein families.
  • Showcased the application of COGs for selecting protein families from specific species sets.
  • Provided a method for discovering previously undetected protein-coding genes.

Conclusions:

  • Phylogenetic patterns are a valuable tool for genome analysis and gene discovery.
  • The COGs database facilitates the identification of functional systems and biochemical pathways.
  • This approach enhances the completeness of genomic information and biological understanding.