Peripheral nerve regeneration along collagen filaments
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Updated: Aug 9, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
Published on: November 21, 2009
1Institute of Biomedical Engineering, Kansai Denryoku Hospital, Imaichi 2-7-14, Asahi-ku, 535-0011, Osaka, Japan. k-20433@kepco.co.jp
Abstract:
This paper describes the regeneration of severed peripheral nerve axons along collagen filaments without a tube. Two thousand collagen filaments were grafted to bridge 20 mm defects of rat sciatic nerve. The number of myelinated axons was approximately 4800 in the distal end of the nerve autograft at 8 weeks postoperatively; while in the collagen-filaments nerve guide it was 5500. The results suggested the collagen filaments guided regenerating axons effectively.
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