Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondrial genomics flies high.

Rand

    Trends in Ecology & Evolution
    |January 9, 2001
    PubMed
    Summary

    Researchers analyzed 28 Drosophila mitochondrial DNA sequences to understand molecular evolution. Findings reveal that DNA sequence evolution deviates from neutral and nearly neutral models.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Does age affect outcome of gastric bypass surgery?

    Current surgery·2000
    Same author

    Intrinsic bistability of luminescence and stimulated emission in Yb- and Tm-doped glass

    Physical review letters·2000
    Same author

    Characterization of the fibre-matrix interfacial structure in carbon fibre-reinforced polycarbosilane-derived SiC matrix composites using STEM/EELS

    Journal of microscopy·1999
    Same author

    Female preferences for temporal order of call components in the túngara frog: a Bayesian analysis.

    Animal behaviour·1999
    Same author

    Evoked vocal response in male túngara frogs: pre-existing biases in male responses?

    Animal behaviour·1999
    Same author

    Phylogenetic influence on mating call preferences in female túngara frogs, Physalaemus pustulosus.

    Animal behaviour·1999

    Area of Science:

    • Evolutionary biology
    • Genomics
    • Molecular evolution

    Background:

    • Mitochondrial DNA (mtDNA) plays a crucial role in cellular respiration and is widely used in evolutionary studies.
    • Neutral and nearly neutral models are standard frameworks for explaining molecular evolution, but their applicability to all genomic regions is debated.

    Purpose of the Study:

    • To investigate the patterns of polymorphism and divergence in Drosophila mitochondrial DNA.
    • To assess whether mtDNA sequence evolution aligns with established neutral and nearly neutral models.
    • To provide a comprehensive whole-genome perspective on mtDNA evolution in Drosophila.

    Main Methods:

    • Sequencing of 28 complete mitochondrial DNA genomes from Drosophila species.
    • Analysis of synonymous and nonsynonymous nucleotide sites within the mtDNA coding sequences.
    • Comparison of observed patterns of polymorphism and divergence against predictions from neutral and nearly neutral models.

    Main Results:

    • The study identified significant departures from neutral and nearly neutral evolution in Drosophila mtDNA.
    • Specific patterns of nucleotide site evolution were observed, indicating selective pressures.
    • A comprehensive whole-genome picture of mtDNA sequence evolution was generated, highlighting deviations from theoretical models.

    Conclusions:

    • Drosophila mitochondrial DNA evolution is not fully explained by strictly neutral or nearly neutral models.
    • Functional constraints and selective pressures likely influence mtDNA sequence evolution.
    • These findings necessitate a re-evaluation of evolutionary models for mitochondrial genomes.

    Related Experiment Videos