Giant coronary aneurysms with multiple vascular aneurysms: a rare manifestation of hyperhomocysteinemia

Area of Science:

• Cardiovascular Medicine
• Vascular Biology
• Metabolic Disorders

Background:

• Hyperhomocysteinemia is a known risk factor for accelerated atherosclerosis and premature vascular disease.
• Previous studies have linked elevated homocysteine levels to various vascular aneurysms.
• Coronary artery aneurysms have not been previously associated with hyperhomocysteinemia.

Observation:

• A patient with diagnosed hyperhomocysteinemia presented with multiple vascular aneurysms.
• The patient exhibited a giant coronary artery aneurysm.
• Peripheral vascular aneurysms were also identified in the same patient.

Findings:

• This case report details the first known instance of a giant coronary artery aneurysm associated with hyperhomocysteinemia.
• The co-occurrence of coronary and peripheral aneurysms in a hyperhomocysteinemic patient highlights a potential pattern of vascular fragility.
• The findings suggest that hyperhomocysteinemia may contribute to the development of aneurysms in both central and peripheral arteries.

Implications:

• This case broadens the understanding of vascular complications associated with hyperhomocysteinemia.
• It suggests that patients with hyperhomocysteinemia may be at increased risk for coronary artery aneurysms.
• Further research is warranted to explore the mechanisms linking hyperhomocysteinemia to coronary and peripheral aneurysms and to inform clinical screening protocols.