Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cell polarity: the PARty expands.

¹Institute of Molecular Biology and the Institute of Neuroscience, HHMI, University of Oregon, Eugene, Oregon 97403, USA. cdoe@uoneuro.uoregon.edu

Nature Cell Biology

|January 9, 2001

Summary

A conserved protein trio regulates cell polarity across diverse cell types. This mechanism is adapted differently, with Drosophila neural precursors showing at least two distinct asymmetric division types.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis.

Development (Cambridge, England)·2001

Same author

Moving muscle. Jeb signaling in Drosophila.

Developmental cell·2001

Same author

Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS.

Development (Cambridge, England)·2001

Same author

Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.

Cell·2001

Same author

Asymmetric cell division: fly neuroblast meets worm zygote.

Current opinion in cell biology·2001

Same author

The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts.

Nature·2000

Area of Science:

Cell biology
Developmental biology
Genetics

Background:

Cell polarity is crucial for tissue organization and development.
An evolutionarily conserved mechanism involving a trio of proteins regulates cell polarity.
This mechanism is adapted for specific cellular functions.

Purpose of the Study:

To investigate the conserved cell polarity mechanism.
To understand how this mechanism is utilized in different cell types, specifically Drosophila neural precursors.

Main Methods:

The study likely involved molecular biology techniques and genetic analysis.
Comparative analysis across different cell types was employed.
Observation of cell division in Drosophila neural precursors was key.

Main Results:

A conserved trio of proteins was identified as key regulators of cell polarity.
The cell polarity mechanism is applied in cell-specific contexts.
At least two distinct types of asymmetric division were observed in Drosophila neural precursors.

Conclusions:

The identified protein trio plays a fundamental role in establishing cell polarity.
Cell-specific adaptations of this conserved mechanism allow for diverse developmental processes.
Asymmetric cell division in neural development is regulated by this conserved pathway.

Related Experiment Videos