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[Chronic autoimmune thyroiditis in the child].

D Marinovic1, J Léger, C Garel

  • 1Service d'endocrinologie et diabétologie pédiatriques, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|January 9, 2001
PubMed
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Chronic autoimmune thyroiditis in children is unpredictable, with some recovering thyroid function. Lifelong monitoring is essential, particularly during pregnancy, to ensure optimal health outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Autoimmune Diseases
  • Thyroid Function

Context:

  • Chronic autoimmune thyroiditis (also known as chronic lymphocytic thyroiditis) is a common endocrine disorder in children.
  • Understanding its clinical course and long-term outcomes is crucial for effective management.

Purpose:

  • To describe the clinical characteristics and long-term follow-up of pediatric patients diagnosed with chronic autoimmune thyroiditis.
  • To investigate the variability in thyroid function over time and identify potential predictive factors.

Summary:

  • A retrospective analysis of 60 children with chronic autoimmune thyroiditis revealed diverse presentations at diagnosis, with many exhibiting hypothyroidism.
  • Thyroid ultrasonography showed characteristic abnormalities in all patients.

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  • During a mean follow-up of 4.4 years, 20% of cases showed altered thyroid function, including recovery in some initially hypothyroid patients.
  • No predictive factors for disease course were identified.
  • All treated children achieved normal final height.

    • Impact:

    • The study highlights the variable and unpredictable natural course of chronic autoimmune thyroiditis in children.
    • Recovery from hypothyroidism is possible, and the L-thyroxine withdrawal test may aid in its assessment.
    • Lifelong thyroid surveillance is recommended, with particular attention to pregnant women to prevent adverse effects on the child.